Cutaneous Apocrine Carcinoma With an In Situ Component and Histiocytoid and Signet-Ring Cells.
Am J Dermatopathol
; 39(6): e76-e78, 2017 Jun.
Article
en En
| MEDLINE
| ID: mdl-28525910
ABSTRACT
We present a case of cutaneous apocrine carcinoma arising in the axilla of a 71-year-old man. The tumor had a significant component of histiocytoid and signet-ring cells as well as in situ carcinoma within the apocrine glands. The cells expressed GATA3, gross cystic disease fluid protein 15, androgen receptor, and E-cadherin. Estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 were negative. Clinical correlation was required to rule out a metastasis from the breast or the gastrointestinal tract. Although most cutaneous apocrine carcinomas do not behave aggressively, our patient developed bone metastases and eventually died of his disease. It is debated whether histiocytoid and signet-ring cell cutaneous carcinomas should be classified as apocrine neoplasm. The presence of in situ carcinoma associated with this kind of tumor has been reported only once in the literature. This characteristic and the immunohistochemical profile are in favor of apocrine differentiation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glándulas Apocrinas
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Neoplasias de las Glándulas Sudoríparas
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Carcinoma in Situ
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Neoplasias Complejas y Mixtas
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Carcinoma de Células en Anillo de Sello
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Histiocitos
Límite:
Aged
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Humans
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Male
Idioma:
En
Revista:
Am J Dermatopathol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Canadá