Enantioselective Nickel-Catalyzed Intramolecular Allylic Alkenylations Enabled by Reversible Alkenylnickel E/Z Isomerization.
Angew Chem Int Ed Engl
; 56(28): 8216-8220, 2017 07 03.
Article
en En
| MEDLINE
| ID: mdl-28544752
ABSTRACT
Enantioselective nickel-catalyzed arylative cyclizations of substrates containing a Z-allylic phosphate tethered to an alkyne are described. These reactions give multisubstituted chiral aza- and carbocycles, and are initiated by the addition of an arylboronic acid to the alkyne, followed by cyclization of the resulting alkenylnickel species onto the allylic phosphate. The reversible E/Z isomerization of the alkenylnickel species is essential for the success of the reactions.
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MEDLINE
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En
Revista:
Angew Chem Int Ed Engl
Año:
2017
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Article
País de afiliación:
Reino Unido