Downregulation of androgen receptors by NaAsO<sub>2</sub> via inhibition of AKT-NF-&#954;B and HSP90 in castration resistant prostate cancer.

Kim, Yunlim; Park, Sang Eun; Moon, Jeong-Weon; Kim, Bong-Min; Kim, Ha-Gyeong; Jeong, In Gab; Yoo, Sangjun; Ahn, Jae Beom; You, Dalsan; Pak, Jhang Ho; Kim, Sujong; Hwang, Jung Jin; Kim, Choung-Soo

Downregulation of androgen receptors by NaAsO₂ via inhibition of AKT-NF-κB and HSP90 in castration resistant prostate cancer.

Kim, Yunlim; Park, Sang Eun; Moon, Jeong-Weon; Kim, Bong-Min; Kim, Ha-Gyeong; Jeong, In Gab; Yoo, Sangjun; Ahn, Jae Beom; You, Dalsan; Pak, Jhang Ho; Kim, Sujong; Hwang, Jung Jin; Kim, Choung-Soo.

Afiliación

Kim Y; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Park SE; Institute for Innovative Cancer Research, Asan Medical Center, Seoul, Korea.
Moon JW; Institute for Innovative Cancer Research, Asan Medical Center, Seoul, Korea.
Kim BM; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Kim HG; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Jeong IG; Institute for Innovative Cancer Research, Asan Medical Center, Seoul, Korea.
Yoo S; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Ahn JB; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
You D; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Pak JH; Department of Urology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Kim S; Asan Institute for Life Science, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Hwang JJ; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Kim CS; Pharmaceutical Division, Komipharm International Co., Ltd., Shiheung, Korea.

Prostate ; 77(10): 1128-1136, 2017 Jul.

Article en En | MEDLINE | ID: mdl-28556958

Asunto(s)

Arsenitos/farmacología; Próstata; Neoplasias de la Próstata Resistentes a la Castración; Receptores Androgénicos/metabolismo; Transducción de Señal/efectos de los fármacos; Compuestos de Sodio/farmacología; Línea Celular Tumoral; Regulación hacia Abajo; Inhibidores Enzimáticos/farmacología; Proteínas HSP90 de Choque Térmico/metabolismo; Humanos; Masculino; FN-kappa B/metabolismo; Próstata/efectos de los fármacos; Próstata/metabolismo; Próstata/patología; Antígeno Prostático Específico/análisis; Neoplasias de la Próstata Resistentes a la Castración/tratamiento farmacológico; Neoplasias de la Próstata Resistentes a la Castración/metabolismo; Neoplasias de la Próstata Resistentes a la Castración/patología; Proteínas Proto-Oncogénicas c-akt/metabolismo; Resultado del Tratamiento

Palabras clave

AKT; HDAC6; NF-κB; PSA; androgen receptor; sodium meta-arsenite

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Próstata / Transducción de Señal / Receptores Androgénicos / Compuestos de Sodio / Arsenitos / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Prostate Año: 2017 Tipo del documento: Article

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