HPV-related vulvar diseases and perspectives of p16INK4a immunochemistry: a review of the literature.
Tumori
; 103(6): 511-515, 2017 Nov 23.
Article
en En
| MEDLINE
| ID: mdl-28574130
ABSTRACT
INTRODUCTION:
Two different types of vulvar intraepithelial neoplasia (VIN), HPV-related and HPV-unrelated, should be considered as two separate entities with different management options. The incidence of HPV-related VIN is increasing worldwide and is implicated in carcinogenesis. Our objective is to investigate the use of p16INK4a immunostaining or p16INK4a/p53 double staining for the detection of HPV-related disease to overcome the problem that histological criteria often have significant overlap.METHODS:
A systematic literature search was carried out in the online databases PubMed, EMBASE, Cochrane Library, Clincaltrials.gov and Scopus. The key search terms were HPV, VIN, p16INK4a immunochemistry and p53.RESULTS:
We found that nuclear and cytoplasmic immunostaining for p16INK4a was intense and diffuse in HPV-associated lesions and weak and focal in normal vulvar epithelium, nondysplastic lesions, lichen sclerosus and keratinizing vulvar squamous cell carcinoma. p53 nuclear immunostaining was always negative in HPV-related disease.CONCLUSIONS:
Our findings indicated that p16INK4a or p16INK4a/p53 immunoreactivity, along with histological diagnosis, could be a convenient means to adequately classify VIN and its connection to HPV infection. Therefore, the clear recognition of HPV-associated VIN would lead to an appropriate strategy of treatment and follow-up.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vulva
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Inmunohistoquímica
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Carcinoma in Situ
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Inhibidor p16 de la Quinasa Dependiente de Ciclina
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Infecciones por Papillomavirus
Tipo de estudio:
Systematic_reviews
Límite:
Female
/
Humans
Idioma:
En
Revista:
Tumori
Año:
2017
Tipo del documento:
Article