Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination.

Mostowy, Rafal J; Croucher, Nicholas J; De Maio, Nicola; Chewapreecha, Claire; Salter, Susannah J; Turner, Paul; Aanensen, David M; Bentley, Stephen D; Didelot, Xavier; Fraser, Christophe

Mostowy, Rafal J; Croucher, Nicholas J; De Maio, Nicola; Chewapreecha, Claire; Salter, Susannah J; Turner, Paul; Aanensen, David M; Bentley, Stephen D; Didelot, Xavier; Fraser, Christophe.

Afiliación

Mostowy RJ; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
Croucher NJ; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
De Maio N; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
Chewapreecha C; Institute for Emerging Infections, Oxford Martin School, Oxford, United Kingdom.
Salter SJ; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
Turner P; Bioinformatics and Systems Biology Program, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Aanensen DM; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.
Bentley SD; Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
Didelot X; Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.
Fraser C; Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.

Mol Biol Evol ; 34(10): 2537-2554, 2017 10 01.

Article en En | MEDLINE | ID: mdl-28595308

Asunto(s)

Cápsulas Bacterianas/genética; Streptococcus pneumoniae/metabolismo; Cápsulas Bacterianas/metabolismo; Evolución Biológica; ADN Bacteriano/genética; Evolución Molecular; Variación Genética; Mutación/genética; Filogenia; Infecciones Neumocócicas; Vacunas Neumococicas; Polisacáridos Bacterianos/genética; Polisacáridos Bacterianos/metabolismo; Recombinación Genética/genética; Serogrupo; Streptococcus/genética; Streptococcus pneumoniae/genética

Palabras clave

conjugate vaccine; epidemiology; evolutionary dynamics; next-generation sequencing; pneumococcal disease; polysaccharide diversity

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Streptococcus pneumoniae / Cápsulas Bacterianas Idioma: En Revista: Mol Biol Evol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Reino Unido

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