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Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
Le, Dung T; Durham, Jennifer N; Smith, Kellie N; Wang, Hao; Bartlett, Bjarne R; Aulakh, Laveet K; Lu, Steve; Kemberling, Holly; Wilt, Cara; Luber, Brandon S; Wong, Fay; Azad, Nilofer S; Rucki, Agnieszka A; Laheru, Dan; Donehower, Ross; Zaheer, Atif; Fisher, George A; Crocenzi, Todd S; Lee, James J; Greten, Tim F; Duffy, Austin G; Ciombor, Kristen K; Eyring, Aleksandra D; Lam, Bao H; Joe, Andrew; Kang, S Peter; Holdhoff, Matthias; Danilova, Ludmila; Cope, Leslie; Meyer, Christian; Zhou, Shibin; Goldberg, Richard M; Armstrong, Deborah K; Bever, Katherine M; Fader, Amanda N; Taube, Janis; Housseau, Franck; Spetzler, David; Xiao, Nianqing; Pardoll, Drew M; Papadopoulos, Nickolas; Kinzler, Kenneth W; Eshleman, James R; Vogelstein, Bert; Anders, Robert A; Diaz, Luis A.
Afiliación
  • Le DT; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Durham JN; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Smith KN; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Wang H; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Bartlett BR; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Aulakh LK; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Lu S; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Kemberling H; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Wilt C; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Luber BS; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Wong F; Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA.
  • Azad NS; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Rucki AA; Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA.
  • Laheru D; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Donehower R; Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA.
  • Zaheer A; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Fisher GA; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Crocenzi TS; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Lee JJ; Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA.
  • Greten TF; Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA.
  • Duffy AG; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Ciombor KK; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Eyring AD; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Lam BH; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Joe A; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Kang SP; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Holdhoff M; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
  • Danilova L; Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cope L; Providence Cancer Center at Providence Health & Services, Portland, OR 97213, USA.
  • Meyer C; Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA.
  • Zhou S; Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Goldberg RM; Gastrointestinal Malignancies Section, Thoracic-GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
  • Armstrong DK; Division of Medical Oncology, Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.
  • Bever KM; Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Fader AN; Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Taube J; Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Housseau F; Merck & Co. Inc., Kenilworth, NJ 07033, USA.
  • Spetzler D; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Xiao N; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Pardoll DM; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Papadopoulos N; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Kinzler KW; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Eshleman JR; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Vogelstein B; Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, MD 21287, USA.
  • Anders RA; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
  • Diaz LA; Ludwig Center and Howard Hughes Medical Institute at Johns Hopkins, Baltimore, MD 21287, USA.
Science ; 357(6349): 409-413, 2017 07 28.
Article en En | MEDLINE | ID: mdl-28596308
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Síndromes Neoplásicos Hereditarios / Neoplasias Encefálicas / Neoplasias Colorrectales / Biomarcadores de Tumor / Anticuerpos Monoclonales Humanizados / Receptor de Muerte Celular Programada 1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Síndromes Neoplásicos Hereditarios / Neoplasias Encefálicas / Neoplasias Colorrectales / Biomarcadores de Tumor / Anticuerpos Monoclonales Humanizados / Receptor de Muerte Celular Programada 1 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Science Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos