Clinical outcomes research in gynecologic oncology.
Gynecol Oncol
; 146(3): 653-660, 2017 09.
Article
en En
| MEDLINE
| ID: mdl-28651803
ABSTRACT
Clinical outcomes research seeks to understand the real-world manifestations of clinical care. In particular, outcomes research seeks to reveal the effects of pharmaceutical, procedural, and structural aspects of healthcare on patient outcomes, including mortality, disease control, toxicity, cost, and quality of life. Although outcomes research can utilize interventional study designs, insightful use of observational data is a defining feature of this field. Many questions in gynecologic oncology are not amenable to investigation in randomized clinical trials due to cost, feasibility, or ethical concerns. When a randomized trial is not practical or has not yet been conducted, well-designed observational studies have the potential to provide the best available evidence about the effects of clinical care. Such studies may use surveys, medical records, disease registries, and a variety of administrative data sources. Even when a randomized trial has been conducted, observational studies can be used to estimate the real-world effect of an intervention, which may differ from the results obtained in the controlled setting of a clinical trial. This article reviews the goals, methodologies, data sources, and limitations of clinical outcomes research, with a focus on gynecologic oncology.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Evaluación de Resultado en la Atención de Salud
/
Investigación Biomédica
/
Neoplasias de los Genitales Femeninos
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Female
/
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Gynecol Oncol
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos