Impact of Different Levels of iPTH on All-Cause Mortality in Dialysis Patients with Secondary Hyperparathyroidism after Parathyroidectomy.
Biomed Res Int
; 2017: 6934706, 2017.
Article
en En
| MEDLINE
| ID: mdl-28656147
ABSTRACT
BACKGROUND:
Secondary hyperparathyroidism (SHPT) usually required parathyroidectomy (PTX) when drugs treatment is invalid. Analysis was done on the impact of different intact parathyroid hormone (iPTH) after the PTX on all-cause mortality.METHODS:
An open, retrospective, multicenter cohort design was conducted. The sample included 525 dialysis patients with SHPT who had undergone PTX.RESULTS:
404 patients conformed to the standard, with 36 (8.91%) deaths during the 11 years of follow-up. One week postoperatively, different levels of serum iPTH were divided into four groups A ≤20 pg/mL; B 21-150 pg/mL; C 151-600 pg/mL; and D >600 pg/mL. All-cause mortality in groups with different iPTH levels appeared as follows A (8.29%), B (3.54%), C (10.91%), and D (29.03%). The all-cause mortality of B was the lowest, with D the highest. We used group A as reference (hazard ratio (HR) = 1) compared with the other groups, and HRs on groups B, C, and D appeared as 0.57, 1.43, and 3.45, respectively.CONCLUSION:
The all-cause mortality was associated with different levels of iPTH after the PTX. We found that iPTH > 600 pg/mL appeared as a factor which increased the risk of all-cause mortality. When iPTH levels were positively and effectively reducing, the risk of all-cause mortality also decreased. The most appropriate level of postoperative iPTH seemed to be 21-150 pg/mL.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hormona Paratiroidea
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Diálisis Renal
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Hiperparatiroidismo Secundario
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Fallo Renal Crónico
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Biomed Res Int
Año:
2017
Tipo del documento:
Article
País de afiliación:
China