Your browser doesn't support javascript.
loading
Unconventional or Preset αß T Cells: Evolutionarily Conserved Tissue-Resident T Cells Recognizing Nonpeptidic Ligands.
Legoux, Francois; Salou, Marion; Lantz, Olivier.
Afiliación
  • Legoux F; Institut Curie, PSL Research University, INSERM, U 932, 75005 Paris, France; email: francois.legoux@curie.fr , marion.salou@curie.fr , olivier.lantz@curie.fr.
  • Salou M; Institut Curie, PSL Research University, INSERM, U 932, 75005 Paris, France; email: francois.legoux@curie.fr , marion.salou@curie.fr , olivier.lantz@curie.fr.
  • Lantz O; Institut Curie, PSL Research University, INSERM, U 932, 75005 Paris, France; email: francois.legoux@curie.fr , marion.salou@curie.fr , olivier.lantz@curie.fr.
Annu Rev Cell Dev Biol ; 33: 511-535, 2017 10 06.
Article en En | MEDLINE | ID: mdl-28661722
A majority of T cells bearing the αß T cell receptor (TCR) are specific for peptides bound to polymorphic classical major histocompatibility complex (MHC) molecules. Smaller subsets of T cells are reactive toward various nonpeptidic ligands associated with nonpolymorphic MHC class-Ib (MHC-Ib) molecules. These cells have been termed unconventional for decades, even though only the composite antigen is different from the one seen by classical T cells. Herein, we discuss the identity of these particular T cells in light of the coevolution of their TCR and MHC-Ib restricting elements. We examine their original thymic development: selection on hematopoietic cells leading to the acquisition of an original differentiation program. Most of these cells acquire memory cell features during thymic maturation and exhibit unique patterns of migration into peripheral nonlymphoid tissues to become tissue resident. Thus, these cells are termed preset T cells, as they also display a variety of effector functions. They may act as microbial or danger sentinels, fight microbes, or regulate tissue homeostasis.
Asunto(s)
Palabras clave

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Linfocitos T / Receptores de Antígenos de Linfocitos T alfa-beta Límite: Animals / Humans Idioma: En Revista: Annu Rev Cell Dev Biol Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos / Linfocitos T / Receptores de Antígenos de Linfocitos T alfa-beta Límite: Animals / Humans Idioma: En Revista: Annu Rev Cell Dev Biol Asunto de la revista: BIOLOGIA Año: 2017 Tipo del documento: Article