Multitasking by Polycomb response elements.
Genes Dev
; 31(11): 1069-1072, 2017 06 01.
Article
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| MEDLINE
| ID: mdl-28717045
ABSTRACT
Development requires the expression of master regulatory genes necessary to specify a cell lineage. Equally significant is the stable and heritable silencing of master regulators that would specify alternative lineages. This regulated gene silencing is carried out by Polycomb group (PcG) proteins, which must be correctly recruited only to the subset of their target loci that requires lineage-specific silencing. A recent study by Erceg and colleagues (pp. 590-602) expands on a key aspect of that targeting The same DNA elements that recruit PcG complexes to a repressed locus also encode transcriptional enhancers that function in different lineages where that locus must be expressed. Thus, PcG targeting elements overlap with enhancers.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Drosophila melanogaster
/
Proteínas del Grupo Polycomb
Límite:
Animals
Idioma:
En
Revista:
Genes Dev
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos