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Solar insolation in springtime influences age of onset of bipolar I disorder.
Bauer, M; Glenn, T; Alda, M; Aleksandrovich, M A; Andreassen, O A; Angelopoulos, E; Ardau, R; Ayhan, Y; Baethge, C; Bharathram, S R; Bauer, R; Baune, B T; Becerra-Palars, C; Bellivier, F; Belmaker, R H; Berk, M; Bersudsky, Y; Bicakci, S; Birabwa-Oketcho, H; Bjella, T D; Bossini, L; Cabrera, J; Cheung, E Y W; Del Zompo, M; Dodd, S; Donix, M; Etain, B; Fagiolini, A; Fountoulakis, K N; Frye, M A; Gonzalez-Pinto, A; Gottlieb, J F; Grof, P; Harima, H; Henry, C; Isometsä, E T; Janno, S; Kapczinski, F; Kardell, M; Khaldi, S; Kliwicki, S; König, B; Kot, T L; Krogh, R; Kunz, M; Lafer, B; Landén, M; Larsen, E R; Lewitzka, U; Licht, R W.
Afiliación
  • Bauer M; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Glenn T; ChronoRecord Association, Fullerton, CA, USA.
  • Alda M; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
  • Aleksandrovich MA; Soviet Psychoneurological Hospital, Urai, Russia.
  • Andreassen OA; NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Angelopoulos E; Department of Psychiatry, Medical School, Eginition Hospital, National and Capodistrian University of Athens, Athens, Greece.
  • Ardau R; Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Sardinia, Italy.
  • Ayhan Y; Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Baethge C; Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany.
  • Bharathram SR; Department of Psychiatry, NIMHANS, Bangalore, India.
  • Bauer R; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Baune BT; Department of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
  • Becerra-Palars C; National Institute of Psychiatry '"Ramón de la Fuente Muñiz", Mexico City, Mexico.
  • Bellivier F; Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, FondaMental Foundation, INSERM UMR-S1144, Denis Diderot University, René Descartes University, Paris, France.
  • Belmaker RH; Department of Psychiatry, Faculty of Health Sciences, Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
  • Berk M; IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Vic., Australia.
  • Bersudsky Y; Department of Psychiatry, Orygen, the National Centre for Excellence in Youth Mental Health, the Centre for Youth Mental Health and the Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Vic., Australia.
  • Bicakci S; Department of Psychiatry, Faculty of Health Sciences, Beer Sheva Mental Health Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
  • Birabwa-Oketcho H; Department of Psychiatry, Hacettepe University Faculty of Medicine, Ankara, Turkey.
  • Bjella TD; Butabika Hospital, Kampala, Uganda.
  • Bossini L; NORMENT - K.G. Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Cabrera J; Department of Molecular Medicine and Department of Mental Health (DAI), University of Siena and University of Siena Medical Center (AOUS), Siena, Italy.
  • Cheung EYW; Mood Disorders Clinic, Dr. Jose Horwitz Psychiatric Institute, Santiago de Chile, Chile.
  • Del Zompo M; Department of General Adult Psychiatry, Castle Peak Hospital, Tuen Mun, Hong Kong.
  • Dodd S; Section of Neurosciences and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Sardinia, Italy.
  • Donix M; IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Vic., Australia.
  • Etain B; Department of Psychiatry, University of Melbourneo, Parkville, Vic, Australia.
  • Fagiolini A; Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Fountoulakis KN; Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, FondaMental Foundation, INSERM UMR-S1144, Denis Diderot University, René Descartes University, Paris, France.
  • Frye MA; Department of Molecular Medicine and Department of Mental Health (DAI), University of Siena and University of Siena Medical Center (AOUS), Siena, Italy.
  • Gonzalez-Pinto A; Division of Neurosciences, 3rd Department of Psychiatry, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Gottlieb JF; Department of Psychiatry & Psychology, Mayo Clinic Depression Center, Mayo Clinic, Rochester, MN, USA.
  • Grof P; Department of Psychiatry, University Hospital of Alava, University of the Basque Country, CIBERSAM, Vitoria, Spain.
  • Harima H; Department of Psychiatry, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
  • Henry C; Mood Disorders Center of Ottawa, University of Toronto, Toronto, ON, Canada.
  • Isometsä ET; Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Tokyo, Japan.
  • Janno S; AP-HP, Hopitaux Universitaires Henri Mondor and INSERM U955 (IMRB) and Université Paris Est and Institut Pasteur, Unité Perception et Mémoire, Paris, France.
  • Kapczinski F; Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Kardell M; National Institute for Health and Welfare, Helsinki, Finland.
  • Khaldi S; Department of Psychiatry, University of Tartu, Tartu, Estonia.
  • Kliwicki S; Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • König B; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Kot TL; Private practice, Tunis, Tunisia.
  • Krogh R; Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
  • Kunz M; BIPOLAR Zentrum Wiener Neustadt, Wiener Neustadt, Austria.
  • Lafer B; Khanty-Mansiysk Clinical Psychoneurological Hospital, Khanty-Mansiysk, Russia.
  • Landén M; Department of Affective Disorders, Q, Mood Disorders Research Unit, Aarhus University Hospital, Aarhus, Denmark.
  • Larsen ER; Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Lewitzka U; Bipolar Disorder Research Program, Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
  • Licht RW; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden.
Acta Psychiatr Scand ; 136(6): 571-582, 2017 Dec.
Article en En | MEDLINE | ID: mdl-28722128
ABSTRACT

OBJECTIVE:

To confirm prior findings that the larger the maximum monthly increase in solar insolation in springtime, the younger the age of onset of bipolar disorder.

METHOD:

Data were collected from 5536 patients at 50 sites in 32 countries on six continents. Onset occurred at 456 locations in 57 countries. Variables included solar insolation, birth-cohort, family history, polarity of first episode and country physician density.

RESULTS:

There was a significant, inverse association between the maximum monthly increase in solar insolation at the onset location, and the age of onset. This effect was reduced in those without a family history of mood disorders and with a first episode of mania rather than depression. The maximum monthly increase occurred in springtime. The youngest birth-cohort had the youngest age of onset. All prior relationships were confirmed using both the entire sample, and only the youngest birth-cohort (all estimated coefficients P < 0.001).

CONCLUSION:

A large increase in springtime solar insolation may impact the onset of bipolar disorder, especially with a family history of mood disorders. Recent societal changes that affect light exposure (LED lighting, mobile devices backlit with LEDs) may influence adaptability to a springtime circadian challenge.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estaciones del Año / Trastorno Bipolar / Internacionalidad / Radiación Electromagnética Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa / America do norte / America do sul / Asia / Europa / Oceania Idioma: En Revista: Acta Psychiatr Scand Año: 2017 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Estaciones del Año / Trastorno Bipolar / Internacionalidad / Radiación Electromagnética Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: Africa / America do norte / America do sul / Asia / Europa / Oceania Idioma: En Revista: Acta Psychiatr Scand Año: 2017 Tipo del documento: Article País de afiliación: Alemania