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Local recurrence of squamous cell carcinoma of the head and neck after radio(chemo)therapy: Diagnostic performance of FDG-PET/MRI with diffusion-weighted sequences.
Becker, Minerva; Varoquaux, Arthur D; Combescure, Christophe; Rager, Olivier; Pusztaszeri, Marc; Burkhardt, Karim; Delattre, Bénédicte M A; Dulguerov, Pavel; Dulguerov, Nicolas; Katirtzidou, Eirini; Caparrotti, Francesca; Ratib, Osman; Zaidi, Habib; Becker, Christoph D.
Afiliación
  • Becker M; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland. Minerva.Becker@hcuge.ch.
  • Varoquaux AD; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland.
  • Combescure C; Department of Radiology, Conception Hospital, Aix-Marseille University, Marseille, France.
  • Rager O; Centre for Clinical Research, Geneva University Hospitals, Geneva, Switzerland.
  • Pusztaszeri M; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland.
  • Burkhardt K; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.
  • Delattre BMA; Division of Clinical Pathology, Geneva University Hospitals, Geneva, Switzerland.
  • Dulguerov P; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland.
  • Dulguerov N; Clinic of Otorhinolaryngology Head and Neck Surgery, Geneva University Hospitals, Geneva, Switzerland.
  • Katirtzidou E; Clinic of Otorhinolaryngology Head and Neck Surgery, Geneva University Hospitals, Geneva, Switzerland.
  • Caparrotti F; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland.
  • Ratib O; Division of Radiation Oncology, Geneva University Hospitals, Geneva, Switzerland.
  • Zaidi H; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland.
  • Becker CD; Department of Imaging, Divisions of Radiology and Nuclear Medicine, Geneva University Hospitals, University of Geneva, Rue, Gabrielle Perret Gentil 4, CH-1211, Geneva 14, Switzerland.
Eur Radiol ; 28(2): 651-663, 2018 Feb.
Article en En | MEDLINE | ID: mdl-28812148
PURPOSE: To determine the diagnostic performance of FDG-PET/MRI with diffusion-weighted imaging (FDG-PET/DWIMRI) for detection and local staging of head and neck squamous cell carcinoma (HNSCC) after radio(chemo)therapy. MATERIALS AND METHODS: This was a prospective study that included 74 consecutive patients with previous radio(chemo)therapy for HNSCC and in whom tumour recurrence or radiation-induced complications were suspected clinically. The patients underwent hybrid PET/MRI examinations with morphological MRI, DWI and FDG-PET. Experienced readers blinded to clinical/histopathological data evaluated images according to established diagnostic criteria taking into account the complementarity of multiparametric information. The standard of reference was histopathology with whole-organ sections and follow-up ≥24 months. Statistical analysis considered data clustering. RESULTS: The proof of diagnosis was histology in 46/74 (62.2%) patients and follow-up (mean ± SD = 34 ± 8 months) in 28/74 (37.8%). Thirty-eight patients had 43 HNSCCs and 46 patients (10 with and 36 without tumours) had 62 benign lesions/complications. Sensitivity, specificity, and positive and negative predictive value of PET/DWIMRI were 97.4%, 91.7%, 92.5% and 97.1% per patient, and 93.0%, 93.5%, 90.9%, and 95.1% per lesion, respectively. Agreement between imaging-based and pathological T-stage was excellent (kappa = 0.84, p < 0.001). CONCLUSION: FDG-PET/DWIMRI yields excellent results for detection and T-classification of HNSCC after radio(chemo)therapy. KEY POINTS: • FDG-PET/DWIMRI yields excellent results for the detection of post-radio(chemo)therapy HNSCC recurrence. • Prospective one-centre study showed excellent agreement between imaging-based and pathological T-stage. • 97.5% of positive concordant MRI, DWI and FDG-PET results correspond to recurrence. • 87% of discordant MRI, DWI and FDG-PET results correspond to benign lesions. • Multiparametric FDG-PET/DWIMRI facilitates planning of salvage surgery in the irradiated neck.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Fluorodesoxiglucosa F18 / Imagen de Difusión por Resonancia Magnética / Tomografía de Emisión de Positrones / Neoplasias de Cabeza y Cuello / Recurrencia Local de Neoplasia Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Radiol Asunto de la revista: RADIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Suiza

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma de Células Escamosas / Fluorodesoxiglucosa F18 / Imagen de Difusión por Resonancia Magnética / Tomografía de Emisión de Positrones / Neoplasias de Cabeza y Cuello / Recurrencia Local de Neoplasia Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Radiol Asunto de la revista: RADIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Suiza