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Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Le Pichon, Claire E; Meilandt, William J; Dominguez, Sara; Solanoy, Hilda; Lin, Han; Ngu, Hai; Gogineni, Alvin; Sengupta Ghosh, Arundhati; Jiang, Zhiyu; Lee, Seung-Hye; Maloney, Janice; Gandham, Vineela D; Pozniak, Christine D; Wang, Bei; Lee, Sebum; Siu, Michael; Patel, Snahel; Modrusan, Zora; Liu, Xingrong; Rudhard, York; Baca, Miriam; Gustafson, Amy; Kaminker, Josh; Carano, Richard A D; Huang, Eric J; Foreman, Oded; Weimer, Robby; Scearce-Levie, Kimberly; Lewcock, Joseph W.
Afiliación
  • Le Pichon CE; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Meilandt WJ; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. lewcock@dnli.com meilandt.william@gene.com.
  • Dominguez S; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Solanoy H; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lin H; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Ngu H; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Gogineni A; Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Sengupta Ghosh A; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Jiang Z; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lee SH; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Maloney J; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Gandham VD; Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Pozniak CD; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wang B; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lee S; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Siu M; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Patel S; Department of Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Modrusan Z; Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Liu X; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Rudhard Y; In Vitro Pharmacology, Evotec AG, Manfred Eigen Campus, 22419 Hamburg, Germany.
  • Baca M; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Gustafson A; Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Kaminker J; Department of Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Carano RAD; Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Huang EJ; Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Foreman O; Pathology Service 113B, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
  • Weimer R; Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Scearce-Levie K; Department of Biomedical Imaging, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Lewcock JW; Department of Neuroscience, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Sci Transl Med ; 9(403)2017 Aug 16.
Article en En | MEDLINE | ID: mdl-28814543
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Leucina Zippers / Enfermedades Neurodegenerativas / Quinasas Quinasa Quinasa PAM Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Leucina Zippers / Enfermedades Neurodegenerativas / Quinasas Quinasa Quinasa PAM Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos