Structural and Functional Impacts of ER Coactivator Sequential Recruitment.

Yi, Ping; Wang, Zhao; Feng, Qin; Chou, Chao-Kai; Pintilie, Grigore D; Shen, Hong; Foulds, Charles E; Fan, Guizhen; Serysheva, Irina; Ludtke, Steven J; Schmid, Michael F; Hung, Mien-Chie; Chiu, Wah; O'Malley, Bert W

Yi, Ping; Wang, Zhao; Feng, Qin; Chou, Chao-Kai; Pintilie, Grigore D; Shen, Hong; Foulds, Charles E; Fan, Guizhen; Serysheva, Irina; Ludtke, Steven J; Schmid, Michael F; Hung, Mien-Chie; Chiu, Wah; O'Malley, Bert W.

Afiliación

Yi P; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Wang Z; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Feng Q; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Chou CK; Departments of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Pintilie GD; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Shen H; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Foulds CE; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Fan G; Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA.
Serysheva I; Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA.
Ludtke SJ; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Schmid MF; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Hung MC; Departments of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Chiu W; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA; National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: wah@bcm.edu.
O'Malley BW; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: berto@bcm.edu.

Mol Cell ; 67(5): 733-743.e4, 2017 Sep 07.

Article en En | MEDLINE | ID: mdl-28844863

Asunto(s)

Proteínas Adaptadoras de Señalización CARD/metabolismo; Proteína p300 Asociada a E1A/metabolismo; Receptor alfa de Estrógeno/metabolismo; Guanilato Ciclasa/metabolismo; Coactivador 3 de Receptor Nuclear/metabolismo; Transcripción Genética; Acetilación; Sitios de Unión; Proteínas Adaptadoras de Señalización CARD/química; Proteínas Adaptadoras de Señalización CARD/genética; Microscopía por Crioelectrón; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Proteína p300 Asociada a E1A/química; Proteína p300 Asociada a E1A/genética; Receptor alfa de Estrógeno/química; Receptor alfa de Estrógeno/genética; Guanilato Ciclasa/química; Guanilato Ciclasa/genética; Células HEK293; Células HeLa; Histonas/química; Histonas/metabolismo; Humanos; Células MCF-7; Metilación; Modelos Moleculares; Complejos Multiproteicos; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Coactivador 3 de Receptor Nuclear/química; Coactivador 3 de Receptor Nuclear/genética; Regiones Promotoras Genéticas; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; Relación Estructura-Actividad; Factores de Tiempo; Factores de Transcripción; Activación Transcripcional; Transfección

Palabras clave

CARM1; SRC-3; coactivator; cryo-EM structure; estrogen receptor; histone modification; p300; sequential recruitment

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transcripción Genética / Receptor alfa de Estrógeno / Proteína p300 Asociada a E1A / Proteínas Adaptadoras de Señalización CARD / Coactivador 3 de Receptor Nuclear / Guanilato Ciclasa Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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