Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function.

Sampaio, Elizabeth P; Ding, Li; Rose, Stacey R; Cruz, Phillip; Hsu, Amy P; Kashyap, Anuj; Rosen, Lindsey B; Smelkinson, Margery; Tavella, Tatyana A; Ferre, Elise M N; Wierman, Meredith K; Zerbe, Christa S; Lionakis, Michail S; Holland, Steven M

Sampaio, Elizabeth P; Ding, Li; Rose, Stacey R; Cruz, Phillip; Hsu, Amy P; Kashyap, Anuj; Rosen, Lindsey B; Smelkinson, Margery; Tavella, Tatyana A; Ferre, Elise M N; Wierman, Meredith K; Zerbe, Christa S; Lionakis, Michail S; Holland, Steven M.

Afiliación

Sampaio EP; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md; Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil. Electronic address: sampaioe@niaid.nih.gov.
Ding L; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Rose SR; Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Md.
Cruz P; Computational Biology Section, Bioinformatics and Computational Biosciences Branch (BCBB), OCICB/OSMO/OD, NIAID, NIH, Bethesda, Md.
Hsu AP; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Kashyap A; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Rosen LB; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Smelkinson M; Biological Imaging Section, NIAID, NIH, Bethesda, Md.
Tavella TA; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Ferre EMN; Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Md.
Wierman MK; Saint Joseph Physician Network Practices, Infectious Diseases, Mishawaka, Ind.
Zerbe CS; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.
Lionakis MS; Fungal Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, NIAID, NIH, Bethesda, Md.
Holland SM; Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Md.

J Allergy Clin Immunol ; 141(5): 1844-1853.e2, 2018 05.

Article en En | MEDLINE | ID: mdl-28859974

Asunto(s)

Mutación con Ganancia de Función/inmunología; Mutación/genética; Factor de Transcripción STAT1/genética; Ubiquitina/genética; Animales; Células COS; Candidiasis Mucocutánea Crónica/genética; Línea Celular; Chlorocebus aethiops; Neoplasias Esofágicas/genética; Carcinoma de Células Escamosas de Esófago/genética; Expresión Génica/genética; Humanos; Fosforilación/genética; Proteína SUMO-1/genética; Sumoilación/genética; Transcripción Genética/genética; Activación Transcripcional/genética; Transfección/métodos

Palabras clave

IFN-Î³; Rhodococcus species infection; Signal transducer and activator of transcription 1; gain of function; small ubiquitin-related modifier; sumoylation

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ubiquitina / Factor de Transcripción STAT1 / Mutación con Ganancia de Función / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2018 Tipo del documento: Article

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