Enhanced thymocyte apoptosis induced by maternal undernutrition in late gestation results in declined mature T cells in rat fetal thymus.
Environ Toxicol Pharmacol
; 56: 50-55, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-28886425
ABSTRACT
This study was designed to observe the effects of maternal food restriction (MFR) on the development of fetal thymus in different gestation periods. Timed pregnant rats were randomized into 3 groups CN (free access to standard chow throughout gestation), MFR0-21 (50% MFR throughout gestation), MFR0-14 (50% MFR from gestational day (GD) 0 to GD14, early-mid gestation). Results showed that MFR during early-mid period had few impact on the fetal thymus and T cell subpopulations. However, MFR throughout gestation resulted in thymic atrophy, deceased frequency of both CD4+ and CD8+ single positive (SP) T cells and enhanced thymocyte apoptosis in fetus. Our results suggest the fetal thymus is more vulnerable to the adverse intrauterine environments in the late gestation period, and the decreased number of SP T cells could result from the enhanced thymocyte apoptosis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Timo
/
Linfocitos T
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Desnutrición
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Timocitos
Límite:
Animals
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Pregnancy
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2017
Tipo del documento:
Article