Radiofrequency electric field hyperthermia with gold nanostructures: role of particle shape and surface chemistry.
Artif Cells Nanomed Biotechnol
; 46(7): 1452-1462, 2018 Nov.
Article
en En
| MEDLINE
| ID: mdl-28891351
ABSTRACT
Hyperthermia treatment of cancerous cells has been recently developed drastically with the help of nanostructures. Heating of gold nanoparticles in non-invasive radiofrequency electric field (RF-EF) is a promising and unique technique for cancer hyperthermia. However, because of differences between particles (i.e. their surface chemistry and dispersion medium) and between RF-EF sources, the research community has not reached a consensus yet. Here, we report the results of investigations on heating of gold nanoparticles and gold nanorods under RF-EF and feasibility of in-vitro cancer hyperthermia. The heating experiments were performed to investigate the role of particle shape and surface chemistry (CTAB, citrate and PEG molecules). In-vitro hyperthermia was performed on human pancreatic cancer cell (MIA Paca-2) with PEG-coated GNPs and GNRs at concentrations that were found non-toxic based on the results of cytotoxicity assay. Application of RF-EF on cells treated with PEG-GNPs and PEG-GNRs proved highly effective in killing cells.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Electricidad
/
Nanopartículas del Metal
/
Terapia por Radiofrecuencia
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Oro
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Hipertermia Inducida
Límite:
Humans
Idioma:
En
Revista:
Artif Cells Nanomed Biotechnol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Irán