Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo.

Martin, Tobias; Möglich, Amelie; Felix, Ina; Förtsch, Christina; Rittlinger, Anne; Palmer, Annette; Denk, Stephanie; Schneider, Julian; Notbohm, Lena; Vogel, Mona; Geiger, Hartmut; Paschke, Stephan; Huber-Lang, Markus; Barth, Holger

Martin, Tobias; Möglich, Amelie; Felix, Ina; Förtsch, Christina; Rittlinger, Anne; Palmer, Annette; Denk, Stephanie; Schneider, Julian; Notbohm, Lena; Vogel, Mona; Geiger, Hartmut; Paschke, Stephan; Huber-Lang, Markus; Barth, Holger.

Afiliación

Martin T; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Möglich A; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Felix I; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Förtsch C; Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
Rittlinger A; Institute of Clinical and Experimental Trauma-Immunology, University of Ulm Medical Center, Helmholtzstrasse 8/2, 89081, Ulm, Germany.
Palmer A; Institute of Clinical and Experimental Trauma-Immunology, University of Ulm Medical Center, Helmholtzstrasse 8/2, 89081, Ulm, Germany.
Denk S; Institute of Clinical and Experimental Trauma-Immunology, University of Ulm Medical Center, Helmholtzstrasse 8/2, 89081, Ulm, Germany.
Schneider J; Department of General and Visceral Surgery, University of Ulm Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Notbohm L; Department of General and Visceral Surgery, University of Ulm Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Vogel M; Institute of Molecular Medicine, University of Ulm, Ulm, Germany.
Geiger H; Institute of Molecular Medicine, University of Ulm, Ulm, Germany.
Paschke S; Division of Experimental Hematology and Cancer Biology, CCHMC, Cincinnati, USA.
Huber-Lang M; Department of General and Visceral Surgery, University of Ulm Medical Center, Albert-Einstein-Allee 23, 89081, Ulm, Germany. stephan.paschke@uniklinik-ulm.de.
Barth H; Institute of Clinical and Experimental Trauma-Immunology, University of Ulm Medical Center, Helmholtzstrasse 8/2, 89081, Ulm, Germany. markus.huber-lang@uniklinik-ulm.de.

Arch Toxicol ; 92(1): 323-336, 2018 Jan.

Article en En | MEDLINE | ID: mdl-28924833

Asunto(s)

ADP Ribosa Transferasas/genética; Toxinas Botulínicas/genética; Quimiotaxis/efectos de los fármacos; Monocitos/efectos de los fármacos; Proteínas Recombinantes de Fusión/farmacología; Proteínas de Unión al GTP rho/antagonistas & inhibidores; Animales; Movimiento Celular/efectos de los fármacos; Células Cultivadas; Modelos Animales de Enfermedad; Humanos; Pulmón/efectos de los fármacos; Pulmón/patología; Macrófagos/efectos de los fármacos; Masculino; Ratones Endogámicos C57BL; Monocitos/citología; Proteínas Recombinantes de Fusión/genética; Traumatismos Torácicos/tratamiento farmacológico; Heridas no Penetrantes/tratamiento farmacológico; Proteínas de Unión al GTP rho/metabolismo

Palabras clave

Chemotaxis; Clostridial C3 toxin; Inflammation; Monocytes; Rho; Trauma

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Toxinas Botulínicas / Proteínas Recombinantes de Fusión / Monocitos / Quimiotaxis / ADP Ribosa Transferasas / Proteínas de Unión al GTP rho Límite: Animals / Humans / Male Idioma: En Revista: Arch Toxicol Año: 2018 Tipo del documento: Article País de afiliación: Alemania

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