Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization.

Ferrara, M; Sessa, G; Fiore, M; Bernard, F; Asteriti, I A; Cundari, E; Colotti, G; Ferla, S; Desideri, M; Buglioni, S; Trisciuoglio, D; Del Bufalo, D; Brancale, A; Degrassi, F

Ferrara, M; Sessa, G; Fiore, M; Bernard, F; Asteriti, I A; Cundari, E; Colotti, G; Ferla, S; Desideri, M; Buglioni, S; Trisciuoglio, D; Del Bufalo, D; Brancale, A; Degrassi, F.

Afiliación

Ferrara M; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Sessa G; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Fiore M; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Bernard F; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Asteriti IA; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Cundari E; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Colotti G; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Ferla S; School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, UK.
Desideri M; Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy.
Buglioni S; Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy.
Trisciuoglio D; Institute of Molecular Biology and Pathology, CNR National Research Council, Rome, Italy.
Del Bufalo D; Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy.
Brancale A; Advanced Diagnostics and Technological Innovation Department, Regina Elena National Cancer Institute, Rome, Italy.
Degrassi F; School of Pharmacy & Pharmaceutical Sciences, Cardiff University, Cardiff, UK.

Oncogene ; 37(2): 231-240, 2018 01 11.

Article en En | MEDLINE | ID: mdl-28925395

Asunto(s)

Antineoplásicos/farmacología; Microtúbulos/efectos de los fármacos; Neoplasias/tratamiento farmacológico; Proteínas Nucleares/antagonistas & inhibidores; Animales; Antineoplásicos/química; Antineoplásicos/uso terapéutico; Apoptosis/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Inestabilidad Cromosómica/efectos de los fármacos; Inestabilidad Cromosómica/genética; Segregación Cromosómica/efectos de los fármacos; Simulación por Computador; Proteínas del Citoesqueleto; Ensayos de Selección de Medicamentos Antitumorales/métodos; Humanos; Concentración 50 Inhibidora; Interfase/efectos de los fármacos; Cinetocoros/metabolismo; Masculino; Ratones; Ratones Desnudos; Microtúbulos/metabolismo; Mitosis/efectos de los fármacos; Simulación del Acoplamiento Molecular; Neoplasias/patología; Proteínas Nucleares/química; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Dominios Proteicos/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Nucleares / Microtúbulos / Neoplasias / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Oncogene Asunto de la revista: BIOLOGIA MOLECULAR / NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Italia

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