Validation of a questionnaire to monitor symptoms in HIV-infected patients during hepatitis C treatment.
AIDS Res Ther
; 14(1): 56, 2017 Sep 20.
Article
en En
| MEDLINE
| ID: mdl-28931406
ABSTRACT
BACKGROUND:
Clinicians are incorporating patient-reported outcomes in the management of HIV-infected persons co-infected with hepatitis C virus (HCV), but there are no validated inventories to monitor symptoms of patients during HCV therapy.DESIGN:
Five-year retrospective cohort analysis of persons living with HIV (PLWH) treated for HCV.METHODS:
The HCV symptom-inventory (HCV-SI) was administered before, during, and after HCV treatment. Discriminant validity was assessed, separately, in mixed model linear regression of HCV-SI T-scores on treatment regimens (pegylated-interferon and ribavirin; pegylated-interferon, ribavirin, and telaprevir; and interferon-free antivirals); and side effect-related premature treatment discontinuation (SE-DC).RESULTS:
From the 103 patients who completed the HCV-SI, 7% were female, 26% non-white, 32% cirrhotics and 91% had undetectable HIV viral loads. Most had genotype 1 (83%) and were HCV treatment-naïve (78%). We treated 19% of patients with pegylated-interferon and ribavirin, 22% with pegylated-interferon, ribavirin, and telaprevir and 59% received interferon-free antivirals. Overall, 77% achieved a sustained virologic response, and 6% discontinued HCV treatment due to side effects. In the treatment discrimination model, compared to the no treatment period, HCV-SI scores were significantly (p < 0.01) lower for interferon-free antivirals and higher for interferon-containing regimens. In the SE-DC model, the total HCV-SI, somatic and neuropsychiatric scores significantly predicted those patients who prematurely discontinued HCV treatment (P < 0.05).CONCLUSIONS:
The HCV-SI effectively differentiated among treatment regimens known to vary by side effect profiles and between patients with and without treatment discontinuation due to side effects. The HCV-SI may have value as a patient-reported outcome instrument predicting the risk of HCV treatment discontinuation.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Infecciones por VIH
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Encuestas y Cuestionarios
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Hepacivirus
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Hepatitis C Crónica
/
Coinfección
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
AIDS Res Ther
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos