Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.

Keeler, Geoffrey D; Kumar, Sandeep; Palaschak, Brett; Silverberg, Emily L; Markusic, David M; Jones, Noah T; Hoffman, Brad E

Keeler, Geoffrey D; Kumar, Sandeep; Palaschak, Brett; Silverberg, Emily L; Markusic, David M; Jones, Noah T; Hoffman, Brad E.

Afiliación

Keeler GD; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Kumar S; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Palaschak B; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Silverberg EL; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Markusic DM; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Jones NT; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA.
Hoffman BE; Division of Cell and Molecular Therapy, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA; Department of Neuroscience, University of Florida, Gainesville, FL 32610, USA. Electronic address: bhoffman@ufl.edu.

Mol Ther ; 26(1): 173-183, 2018 01 03.

Article en En | MEDLINE | ID: mdl-28943274

Asunto(s)

Epítopos de Linfocito T/inmunología; Terapia Genética; Esclerosis Múltiple/genética; Esclerosis Múltiple/inmunología; Linfocitos T Reguladores/inmunología; Linfocitos T Reguladores/metabolismo; Animales; Autoinmunidad; Biomarcadores; Dependovirus/genética; Modelos Animales de Enfermedad; Encefalomielitis Autoinmune Experimental; Terapia Genética/métodos; Vectores Genéticos/genética; Hepatocitos/inmunología; Hepatocitos/metabolismo; Tolerancia Inmunológica; Hígado/metabolismo; Ratones; Esclerosis Múltiple/metabolismo; Esclerosis Múltiple/terapia; Médula Espinal/metabolismo; Médula Espinal/patología

Palabras clave

adeno associated virus; autoimmunity; experimental autoimmune encephalomyelitis; gene therapy; immunotherapy; regulatory T cell; tolerance; viral vector

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Terapia Genética / Linfocitos T Reguladores / Epítopos de Linfocito T / Esclerosis Múltiple Límite: Animals Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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