Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes.
Cardiovasc Diabetol
; 16(1): 120, 2017 09 29.
Article
en En
| MEDLINE
| ID: mdl-28962617
ABSTRACT
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Estrés Oxidativo
/
Mediadores de Inflamación
/
Diabetes Mellitus
/
Obesidad
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cardiovasc Diabetol
Asunto de la revista:
ANGIOLOGIA
/
CARDIOLOGIA
/
ENDOCRINOLOGIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos