Inflammatory response to mental stress and mental stress induced myocardial ischemia.
Brain Behav Immun
; 68: 90-97, 2018 02.
Article
en En
| MEDLINE
| ID: mdl-28986223
ABSTRACT
BACKGROUND:
Mental stress-induced myocardial ischemia (MSIMI) is associated with increased risk of adverse cardiovascular outcomes, yet the underlying mechanisms are not well understood. We measured the inflammatory response to acute laboratory mental stress in patients with coronary artery disease (CAD) and its association with MSIMI. We hypothesized that patients with MSIMI would have a higher inflammatory response to mental stress in comparison to those without ischemia.METHODS:
Patients with stable CAD underwent 99mTc sestamibi myocardial perfusion imaging during mental stress testing using a public speaking stressor. MSIMI was determined as impaired myocardial perfusion using a 17-segment model. Inflammatory markers including interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), matrix metallopeptidase 9 (MMP-9) and high-sensitivity C reactive protein (hsCRP) were measured at rest and 90â¯min after mental stress. Results were validated in an independent sample of 228 post-myocardial infarction patients.RESULTS:
Of 607 patients analyzed in this study, (mean age 63⯱â¯9â¯years, 76% male), 99 (16.3%) developed MSIMI. Mental stress resulted in a significant increase in IL-6, MCP-1, and MMP-9 (all pâ¯<0.0001), but not hsCRP. However, the changes in these markers were similar in those with and without MSIMI. Neither resting levels of these biomarkers, nor their changes with mental stress were significantly associated with MSIMI. Results in the replication sample were similar.CONCLUSION:
Mental stress is associated with acute increases in several inflammatory markers. However, neither the baseline inflammatory status nor the magnitude of the inflammatory response to mental stress over 90â¯min were significantly associated with MSIMI.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estrés Psicológico
/
Isquemia Miocárdica
Tipo de estudio:
Prognostic_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Brain Behav Immun
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
CEREBRO
/
PSICOFISIOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos