Sponge Spray-Reaching New Dimensions of Direct Sampling and Analysis by MS.
Anal Chem
; 89(21): 11592-11597, 2017 11 07.
Article
en En
| MEDLINE
| ID: mdl-29028329
ABSTRACT
Sample preparation for the analysis of clinical samples with the mass spectrometer (MS) can be extensive and expensive. Simplifying and speeding up the process would be very beneficial. This paper reports sponge spray-a novel sampling and direct MS analysis approach-attempting exactly that. It enables direct analysis without any sample preparation from dried blood, plasma, and urine. The tip of a volumetric absorptive microsampling device is used to collect an exact amount of sample and from that same tip an electrospray can be directed into a mass spectrometer. We demonstrate here that, although with significant matrix effects, quantitation of penicillin G, a common antimicrobial, is possible in plasma and in urine, with essentially no sample preparation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Espectrometría de Masas
/
Métodos Analíticos de la Preparación de la Muestra
Límite:
Humans
Idioma:
En
Revista:
Anal Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estonia