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Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment.
Trojani, Alessandra; Pungolino, Ester; Rossi, Giuseppe; D'Adda, Mariella; Lodola, Milena; Camillo, Barbara Di; Perego, Alessandra; Turrini, Mauro; Orlandi, Ester; Borin, Lorenza; Iurlo, Alessandra; Malato, Simona; Spina, Francesco; Latargia, Maria Luisa; Lanza, Francesco; Artale, Salvatore; Anghilieri, Michela; Carraro, Maria Cristina; Canal, Gabriella De; Morra, Enrica; Cairoli, Roberto.
Afiliación
  • Trojani A; Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Pungolino E; Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Rossi G; Department of Hematology, ASST Spedali Civili, Brescia, Italy.
  • D'Adda M; Department of Hematology, ASST Spedali Civili, Brescia, Italy.
  • Lodola M; Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Camillo BD; Department of Information Engineering, University of Padova, Padova, Italy.
  • Perego A; Internal Medicine-Haematology, Desio Hospital, Desio, Italy.
  • Turrini M; Division of Hematology, Department of Internal Medicine, Valduce Hospital, Como, Italy.
  • Orlandi E; Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Borin L; Hematology Division, San Gerardo Hospital, Monza, Italy.
  • Iurlo A; Oncohematology Division, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, Milano, Italy.
  • Malato S; Hematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano, Italy.
  • Spina F; Division of Hematology - Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
  • Latargia ML; ASST Valle Olona Ospedale di Circolo, Busto Arsizio, Italy.
  • Lanza F; Division of Hematology, Hospital of Cremona, Cremona, Italy.
  • Artale S; ASST Valle Olona Sant'Antonio Abate, Gallarate, Italy.
  • Anghilieri M; ASST Lecco, Lecco, Italy.
  • Carraro MC; Hematology and Transfusion Medicine, Sacco Hospital, Milano, Italy.
  • Canal G; Pathology Department, Cytogenetics, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  • Morra E; Executive Committee, Rete Ematologia Lombarda, Italy.
  • Cairoli R; Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Cancer Biomark ; 21(1): 41-53, 2017 Dec 12.
Article en En | MEDLINE | ID: mdl-29036785
ABSTRACT

BACKGROUND:

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined.

OBJECTIVE:

We undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin- cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirimidinas / Células de la Médula Ósea / Leucemia Mieloide de Fase Crónica / Perfilación de la Expresión Génica Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Humans Idioma: En Revista: Cancer Biomark Asunto de la revista: BIOQUIMICA / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Italia
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Pirimidinas / Células de la Médula Ósea / Leucemia Mieloide de Fase Crónica / Perfilación de la Expresión Génica Tipo de estudio: Clinical_trials / Diagnostic_studies Límite: Humans Idioma: En Revista: Cancer Biomark Asunto de la revista: BIOQUIMICA / NEOPLASIAS Año: 2017 Tipo del documento: Article País de afiliación: Italia