Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the &#945;7 neuronal nicotinic receptor.

Cook, James; Zusi, F Christopher; Hill, Matthew D; Fang, Haiquan; Pearce, Bradley; Park, Hyunsoo; Gallagher, Lizbeth; McDonald, Ivar M; Bristow, Linda; Macor, John E; Olson, Richard E

Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.

Cook, James; Zusi, F Christopher; Hill, Matthew D; Fang, Haiquan; Pearce, Bradley; Park, Hyunsoo; Gallagher, Lizbeth; McDonald, Ivar M; Bristow, Linda; Macor, John E; Olson, Richard E.

Afiliación

Cook J; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA. Electronic address: jim.cook@bms.com.
Zusi FC; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Hill MD; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Fang H; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Pearce B; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Park H; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Gallagher L; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
McDonald IM; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Bristow L; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Macor JE; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.
Olson RE; Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.

Bioorg Med Chem Lett ; 27(22): 5002-5005, 2017 11 15.

Article en En | MEDLINE | ID: mdl-29050783

Asunto(s)

Compuestos Bicíclicos con Puentes/metabolismo; Diseño de Fármacos; Octanos/metabolismo; Receptor Nicotínico de Acetilcolina alfa 7/metabolismo; Compuestos Bicíclicos con Puentes/síntesis química; Compuestos Bicíclicos con Puentes/química; Cristalografía por Rayos X; Humanos; Enlace de Hidrógeno; Conformación Molecular; Agonistas Nicotínicos/química; Agonistas Nicotínicos/metabolismo; Octanos/síntesis química; Octanos/química; Unión Proteica; Receptores de Serotonina 5-HT3/química; Receptores de Serotonina 5-HT3/metabolismo; Estereoisomerismo; Receptor Nicotínico de Acetilcolina alfa 7/química

Palabras clave

5-HT(3A) receptor; Schizophrenia; Spirooxazolines; α7 nicotinic acetylcholine receptor

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Compuestos Bicíclicos con Puentes / Diseño de Fármacos / Receptor Nicotínico de Acetilcolina alfa 7 / Octanos Límite: Humans Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2017 Tipo del documento: Article

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