Glucagon-like peptide-1 levels and dipeptidyl peptidase-4 activity in type 2 diabetes.
Clin Invest Med
; 40(5): E188-E199, 2017 10 19.
Article
en En
| MEDLINE
| ID: mdl-29061224
ABSTRACT
PURPOSE:
Hyperglycemia is the major risk factor for microvascular complications in type 2 diabetes mellitus (T2DM) patients. This randomized controlled clinical trial aimed to investigate T2DM patients with microvascular complications with regard to possible relations among serum clusterin (CLU), amylin, secreted frizzled-related protein-4 (SFRP-4), glucagon-like peptide-1 (GLP-1) and dipeptidyl peptidase-4 (DPP-4) activities.METHODS:
Subject groups were defined as follows T2DM without complications (n=25, F/M=9/16, age 53.9±11.1 years); T2DM+Retinopathy (n=25, F/M=13/12, age 63.8±7.1 years); T2DM+Nephropathy (n=25, F/M=13/12, age 58.7±14.4 years); T2DM+Neuropathy (n=25, F/M=15/10, age 63.2±9.6 years); and healthy control subjects (HC) (n=25). CLU, amylin, SFRP-4, DPP-4 and GLP-1 (total and active) activities were measured and compared in blood samples from type 2 diabetic patients with and without microvascular complications.RESULTS:
Significantly lower levels of DPP-4 and GLP-1total (P.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dipeptidil Peptidasa 4
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Diabetes Mellitus Tipo 2
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Nefropatías Diabéticas
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Retinopatía Diabética
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Péptido 1 Similar al Glucagón
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Hiperglucemia
Tipo de estudio:
Clinical_trials
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Invest Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
Turquía