Mechanochemical Knoevenagel condensation investigated in situ.
Beilstein J Org Chem
; 13: 2010-2014, 2017.
Article
en En
| MEDLINE
| ID: mdl-29062421
ABSTRACT
The mechanochemical Knoevenagel condensation of malononitrile with p-nitrobenzaldehyde was studied in situ using a tandem approach. X-ray diffraction and Raman spectroscopy were combined to yield time-resolved information on the milling process. Under solvent-free conditions, the reaction leads to a quantitative conversion to p-nitrobenzylidenemalononitrile within 50 minutes. The in situ data indicate that the process is fast and proceeds under a direct conversion. After stopping the milling process, the reaction continues until complete conversion. The continuous and the stopped milling process both result in crystalline products suitable for single crystal X-ray diffraction.
Texto completo:
1
Bases de datos:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Año:
2017
Tipo del documento:
Article
País de afiliación:
Alemania