Recruitment of the amyloid precursor protein by γ-secretase at the synaptic plasma membrane.
Biochem Biophys Res Commun
; 498(2): 334-341, 2018 03 29.
Article
en En
| MEDLINE
| ID: mdl-29097209
ABSTRACT
Γ-secretase is a membrane-embedded protease that cleaves single transmembrane helical domains of various integral membrane proteins. The amyloid precursor protein (APP) is an important substrate due to its pathological relevance to Alzheimer's disease. The mechanism of the cleavage of APP by γ-secretase that leads to accumulation of Alzheimer's disease causing amyloid-ß (Aß) is still unknown. Coarse-grained molecular dynamics simulations in this study reveal initial lipids raft formation near the catalytic site of γ-secretase as well as changes in dynamic behavior of γ-secretase once interacting with APP. The results suggest a precursor of the APP binding mode and hint at conformational changes of γ-secretase in the nicastrin (NCT) domain upon APP binding.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Membranas Sinápticas
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Precursor de Proteína beta-Amiloide
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Secretasas de la Proteína Precursora del Amiloide
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Simulación de Dinámica Molecular
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
2018
Tipo del documento:
Article
País de afiliación:
Suiza