Peptide transporter YjiY influences the expression of the virulence gene mgtC to regulate biofilm formation in Salmonella.
FEMS Microbiol Lett
; 364(24)2017 12 29.
Article
en En
| MEDLINE
| ID: mdl-29112725
ABSTRACT
Formation of a biofilm is one of the coping strategies of Salmonella against antimicrobial environmental stresses including nutrient starvation. However, the channeling of the starvation cue towards biofilm formation is not well understood. Our study shows that a carbon starvation gene, yjiY, coding for a peptide transporter, influences the expression of a virulence-associated gene mgtC in Salmonella to regulate biofilm formation. We demonstrate here that the mutant strain ΔyjiY is unable to form a biofilm due to the increased expression of mgtC. The upregulation of mgtC in the ΔyjiY strain correlates with the downregulation of the biofilm master regulator gene, csgD, and reduced levels of ATP. Our work further indicates that a yjiY-encoded peptide transporter may regulate the expression of mgtC by transporting proline peptides.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
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Salmonella typhimurium
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Proteínas Bacterianas
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Regulación Bacteriana de la Expresión Génica
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Biopelículas
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Proteínas de Transporte de Catión
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
2017
Tipo del documento:
Article
País de afiliación:
India