CK-2127107 amplifies skeletal muscle response to nerve activation in humans.
Muscle Nerve
; 57(5): 729-734, 2018 05.
Article
en En
| MEDLINE
| ID: mdl-29150952
ABSTRACT
INTRODUCTION:
Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK-2127107 (CK-107), a next-generation fast skeletal muscle troponin activator (FSTA), in healthy participants. We tested the hypothesis that CK-107 would amplify the force-frequency response of muscle in humans.METHODS:
To assess the force-frequency response, participants received single doses of CK-107 and placebo in a randomized, double-blind, 4-period, crossover study. The force-frequency response of foot dorsiflexion following stimulation of the deep fibular nerve to activate the tibialis anterior muscle was assessed.RESULTS:
CK-107 significantly increased tibialis anterior muscle response with increasing dose and plasma concentration in a frequency-dependent manner; the largest increase in peak force was â¼60% at 10 Hz.DISCUSSION:
CK-107 appears more potent and produced larger increases in force than tirasemtiv-a first-generation FSTA-in a similar pharmacodynamic study, thereby supporting its development for improvement of muscle function of patients. Muscle Nerve 57 729-734, 2018.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Troponina
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Músculo Esquelético
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Fibras Musculares de Contracción Rápida
Tipo de estudio:
Clinical_trials
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Prognostic_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Muscle Nerve
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos