LGL leukemia and autoimmunity - the borderline between autoimmune disease and cancer is becoming blurred.
Duodecim
; 132(15): 1328-35, 2016.
Article
en En
| MEDLINE
| ID: mdl-29160632
ABSTRACT
Large granular lymphocyte (LGL) leukemia is a chronic hematological disease, in which the diseased cells consist of clonal large, mature T or NK cells. Major symptoms and findings of the disease include anemia, neutropenia and rheumatoid arthritis. Immunosuppressive treatments, such as methotrexate, usually relieve the symptoms in patients. In LGL leukemia, next-generation sequencing has recently revealed mutations in the STAT3 and STAT5B genes that lead to the activation of these proteins. Similar mutations have been detected in hereditary autoimmune diseases, disorders of bone marrow and malignancies of lymphocyte origin.
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Bases de datos:
MEDLINE
Asunto principal:
Autoinmunidad
/
Leucemia Linfocítica Granular Grande
/
Inmunoterapia
/
Mutación
Límite:
Humans
Idioma:
En
Revista:
Duodecim
Año:
2016
Tipo del documento:
Article