Low-fat yogurt consumption reduces biomarkers of chronic inflammation and inhibits markers of endotoxin exposure in healthy premenopausal women: a randomised controlled trial.
Br J Nutr
; 118(12): 1043-1051, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-29179781
ABSTRACT
The anti-inflammatory mechanisms of low-fat dairy product consumption are largely unknown. The objective of this study was to determine whether low-fat yogurt reduces biomarkers of chronic inflammation and endotoxin exposure in women. Premenopausal women (BMI 18·5-27 and 30-40 kg/m2) were randomised to consume 339 g of low-fat yogurt (yogurt non-obese (YN); yogurt obese (YO)) or 324 g of soya pudding (control non-obese; control obese (CO)) daily for 9 weeks (n 30/group). Fasting blood samples were analysed for IL-6, TNF-α/soluble TNF II (sTNF-RII), high-sensitivity C-reactive protein, 2-arachidonoyl glycerol, anandamide, monocyte gene expression, soluble CD14 (sCD14), lipopolysaccharide (LPS), LPS binding protein (LBP), IgM endotoxin-core antibody (IgM EndoCAb), and zonulin. BMI, waist circumference and blood pressure were also determined. After 9-week yogurt consumption, YO and YN had decreased TNF-α/sTNFR-RII. Yogurt consumption increased plasma IgM EndoCAb regardless of obesity status. sCD14 was not affected by diet, but LBP/sCD14 was lowered by yogurt consumption in both YN and YO. Yogurt intervention increased plasma 2-arachidonoylglycerol in YO but not YN. YO peripheral blood mononuclear cells expression of NF-κB inhibitor α and transforming growth factor ß1 increased relative to CO at 9 weeks. Other biomarkers were unchanged by diet. CO and YO gained approximately 0·9 kg in body weight. YO had 3·6 % lower diastolic blood pressure at week 3. Low-fat yogurt for 9 weeks reduced biomarkers of chronic inflammation and endotoxin exposure in premenopausal women compared with a non-dairy control food. This trial was registered as NCT01686204.
Palabras clave
2-AG 2-arachidonoylglycerol; AEA anandamide; CO control obese; IgM EndoCAb IgM endotoxin-core antibody; LBP lipopolysaccharide-binding protein; LPS lipopolysaccharide; TLR4 Toll-like receptor 4; YN yogurt non-obese; YO yogurt obese; sCD14 soluble CD14; Chronic inflammation; Dairy products; Endotoxin exposure; Low-fat yogurt; Obesity
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Yogur
/
Biomarcadores
/
Dieta
/
Endotoxinas
/
Inflamación
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Br J Nutr
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos