A neutralizing antibody that blocks delivery of the enzymatic cargo of <i>Clostridium difficile</i> toxin TcdB into host cells.

Kroh, Heather K; Chandrasekaran, Ramyavardhanee; Zhang, Zhifen; Rosenthal, Kim; Woods, Rob; Jin, Xiaofang; Nyborg, Andrew C; Rainey, G Jonah; Warrener, Paul; Melnyk, Roman A; Spiller, Benjamin W; Lacy, D Borden

A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells.

Kroh, Heather K; Chandrasekaran, Ramyavardhanee; Zhang, Zhifen; Rosenthal, Kim; Woods, Rob; Jin, Xiaofang; Nyborg, Andrew C; Rainey, G Jonah; Warrener, Paul; Melnyk, Roman A; Spiller, Benjamin W; Lacy, D Borden.

Afiliación

Kroh HK; From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2363.
Chandrasekaran R; From the Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2363.
Zhang Z; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Rosenthal K; Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Woods R; MedImmune LLC, Gaithersburg, Maryland 20878-2204.
Jin X; MedImmune LLC, Gaithersburg, Maryland 20878-2204.
Nyborg AC; MedImmune LLC, Gaithersburg, Maryland 20878-2204.
Rainey GJ; MedImmune LLC, Gaithersburg, Maryland 20878-2204.
Warrener P; MedImmune LLC, Gaithersburg, Maryland 20878-2204.
Melnyk RA; MedImmune LLC, Gaithersburg, Maryland 20878-2204.
Spiller BW; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Lacy DB; Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.

J Biol Chem ; 293(3): 941-952, 2018 01 19.

Article en En | MEDLINE | ID: mdl-29180448

Asunto(s)

Anticuerpos Neutralizantes/metabolismo; Toxinas Bacterianas/metabolismo; Clostridioides difficile/metabolismo; Enterotoxinas/metabolismo; Anticuerpos Monoclonales/metabolismo; Toxinas Bacterianas/química; Células CACO-2; Clostridioides difficile/enzimología; Cristalografía por Rayos X; Citosol/metabolismo; Enterotoxinas/química; Humanos; Concentración de Iones de Hidrógeno; Microscopía Electrónica; Rubidio/química; Proteína de Unión al GTP rac1/química; Proteína de Unión al GTP rac1/metabolismo

Palabras clave

X-ray crystallography; antibody; bacterial pathogenesis; bacterial toxin; electron microscopy (EM); membrane transport; neutralization; toxin

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Toxinas Bacterianas / Clostridioides difficile / Enterotoxinas / Anticuerpos Neutralizantes Límite: Humans Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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