The effect of non-steroidal anti-inflammatory drugs on severity of acute pancreatitis and pancreatic necrosis.
Ann R Coll Surg Engl
; 100(3): 199-202, 2018 Mar.
Article
en En
| MEDLINE
| ID: mdl-29181999
ABSTRACT
Introduction Acute pancreatitis (AP) is a common emergency presentation and can be disabling. There is significant morbidity and mortality associated with AP, and it places a considerable burden on the healthcare system. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to have a protective effect in some elective contexts. This retrospective study aimed to evaluate the effect of NSAIDs on the course of AP and the severity of the disease. Methods A retrospective analysis was carried out of 324 patients admitted as an emergency with a diagnosis of AP to two UK hospitals. Patients were divided into two groups those already taking NSAIDs for other co-morbidities and those not taking NSAIDs. Variables compared included admission to a high dependency or intensive care unit; pancreatic necrosis; pseudocyst development; need for surgery; serum inflammatory markers; modified early warning scores on days 1, 3 and 5; length of stay; and mortality. Results Patients not taking NSAIDs were more likely to have a C-reactive protein level of ≥150mg/l (p=0.007). Patients in the NSAID group experienced less pancreatic necrosis (p=0.019) and lower rates of pseudocyst formation (p=0.010). Other variables showed no difference between the two groups, specifically length of stay and mortality. Conclusions Routine NSAID use may exert a protective effect on the development of AP, its severity, and complications. Therapeutic use of NSAIDs in acute presentations with pancreatitis should be further evaluated.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Pancreatitis
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Antiinflamatorios no Esteroideos
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann R Coll Surg Engl
Año:
2018
Tipo del documento:
Article
País de afiliación:
Reino Unido