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Altered resting-state brain activity in Parkinson's disease patients with freezing of gait.
Mi, Tao-Mian; Mei, Shan-Shan; Liang, Pei-Peng; Gao, Lin-Lin; Li, Kun-Cheng; Wu, Tao; Chan, Piu.
Afiliación
  • Mi TM; Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.
  • Mei SS; Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.
  • Liang PP; Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
  • Gao LL; Beijing Key Laboratory of MRI and Brain Informatics, Beijing, 100053, China.
  • Li KC; Department of Neurology, Neurobiology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing Institute of Brain Disorders, Beijing, 100053, China.
  • Wu T; Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China.
  • Chan P; Beijing Key Laboratory of MRI and Brain Informatics, Beijing, 100053, China.
Sci Rep ; 7(1): 16711, 2017 12 01.
Article en En | MEDLINE | ID: mdl-29196699
Freezing of gait (FOG) is a common and debilitating symptom in Parkinson's disease (PD). The current study investigated alterations of resting-state spontaneous brain activity in PD patients with FOG. A total of 29 patients with FOG, 28 patients without FOG and 31 controls were included. All subjects underwent resting-state functional MRI, and the amplitude of low-frequency fluctuation (ALFF) was calculated to measure the spontaneous brain activity. Between-group differences and correlations with FOG severity (both subjective and objective measures) were analyzed. Compared to those without FOG, patients with FOG showed increased ALFF in right anterior cingulate cortex (ACC) and left inferior parietal lobule (IPL), as well as decreased ALFF in right superior frontal gyrus (SFG), bilateral cerebellum and left thalamus. Correlation analyses demonstrated that ALFF within the right SFG, right ACC and bilateral pallidum were positively correlated with FOG; while ALFF within the thalamus, putamen, cerebellum and sensorimotor regions were negatively correlated. Our results indicate that FOG is associated with dysfunction within frontal-parietal regions, along with increased inhibitory outputs from basal ganglia. Additionally, altered activity of cerebellum implicates its role in the pathophysiology of FOG. These findings provide further insight into the underlying neural mechanisms of FOG in PD patients.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha / Marcha Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha / Marcha Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China