First case report of using Ofatumumab in kidney transplantation AB0 incompatible. / PRIMO CASE REPORT DI UTILIZZO DELL' OFATUMUMAB NEL TRAPIANTO RENALE AB0 INCOMPATIBILE.
G Ital Nefrol
; 34(Nov-Dec)2017 Dec 05.
Article
en En, It
| MEDLINE
| ID: mdl-29207227
ABSTRACT
Modern methods for desensitization protocol rely heavily on combined apheresis therapy and Rituximab, a chimeric (murine and human) anti-CD20 antibody used in AB0 incompatible kidney transplants. Severe infusion related reactions due to the administration of Rituximab are reported in 10% of patients. These adverse reactions may hinder the completion of the desensitization protocol. Therefore, it's useful to test alternative B cell depleting therapies. Our clinical case focuses on a 41-year-old male who developed an adverse infusion reaction following the administration of Rituximab and was given Ofatumumab as an alternative treatment. Ofatumumab is a fully humanized monoclonal anti-CD20 antibody. As a fully humanized antibody, Ofatumumab may avoid immunogenic reactions. The patient tolerated the administration of the drug showing no signs of adverse side effects and with good clinical efficacy. Our case report suggest that Ofatumumab is a valid alternative B cell depleting agent.
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Bases de datos:
MEDLINE
Asunto principal:
Incompatibilidad de Grupos Sanguíneos
/
Sistema del Grupo Sanguíneo ABO
/
Depleción Linfocítica
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Trasplante de Riñón
/
Anticuerpos Monoclonales
Tipo de estudio:
Etiology_studies
/
Guideline
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
/
It
Revista:
G Ital Nefrol
Asunto de la revista:
NEFROLOGIA
Año:
2017
Tipo del documento:
Article