Unsaturated cryptophanes: Toward dual PHIP/hyperpolarised xenon sensors.
Magn Reson Chem
; 56(7): 672-678, 2018 07.
Article
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| MEDLINE
| ID: mdl-29218737
ABSTRACT
Cryptophanes, cage-molecules constituted of aromatic bowls, are now well recognised as powerful xenon hosts in 129 Xe NMR-based biosensing. In the quest of a dual probe that can be addressed only by NMR, we have studied three cryptophanes bearing a tether with an unsaturated bond. The idea behind this is to build probes that can be detected both via hyperpolarised 129 Xe NMR and para-hydrogen induced polarisation 1 H NMR. Only two of the three cryptophanes experience a sufficiently fast hydrogenation enabling the para-hydrogen induced polarisation effect. Although the in-out xenon exchange properties are maintained after hydrogenation, the chemical shift of xenon encaged in these two cryptophanes is not strikingly modified, which impedes safe discrimination of the native and hydrogenated states via 129 Xe NMR. However, a thorough examination of the hyperpolarised 1 H spectra reveals some interesting features for the catalytic process and gives us clues for the design of doubly smart 1 H/129 Xe NMR-based biosensors.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
Magn Reson Chem
Asunto de la revista:
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia