Exposure to vitamin D from fortified margarine during fetal life and later risk of pre-eclampsia: the D-tect Study.
Public Health Nutr
; 21(4): 721-731, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29258625
ABSTRACT
OBJECTIVE:
To examine if fetal exposure to a small dosage of extra vitamin D from food fortification was associated with a decrease in the risk of pre-eclampsia later in life.DESIGN:
Cancellation of the mandatory vitamin D fortification of margarine in 1985 created a societal experiment, with entire adjacent birth cohorts exposed or unexposed to extra vitamin D during fetal development. The Danish national medical health registries allowed the identification of pre-eclampsia cases later in life among all exposed and unexposed female individuals.SETTING:
Denmark.SUBJECTS:
Women born between June 1983 and August 1988, who gave birth to their first child at age 14·5-27·5 years (n 32 621).RESULTS:
OR (95 % CI) for pre-eclampsia among women exposed v. unexposed to extra vitamin D from fortification during fetal development was 0·86 (0·76, 0·97). Exposure to extra vitamin D was associated with further reduced odds of pre-eclampsia (0·49 (0·34, 0·72)) among current smokers, but not among former smokers and non-smokers.CONCLUSIONS:
Additional vitamin D in fetal life from food fortification seems to reduce the risk of pre-eclampsia later in life. The risk reduction may be particularly strong among women who smoke during pregnancy.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Preeclampsia
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Vitamina D
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Alimentos Fortificados
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Fenómenos Fisiologicos de la Nutrición Prenatal
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Desarrollo Fetal
/
Margarina
Tipo de estudio:
Etiology_studies
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Incidence_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
País/Región como asunto:
Europa
Idioma:
En
Revista:
Public Health Nutr
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
SAUDE PUBLICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Dinamarca