Clinical Trial of Radiotherapy After Intravenous Injection of Acridine Orange for Patients with Cancer.
Anticancer Res
; 38(1): 481-489, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-29277813
ABSTRACT
AIM:
We previously found that low-dose X-ray treatment after systemic administration of acridine orange (AO), which is known to have a low toxicity in animals, inhibited tumor growth in experimental studies using mouse osteosarcoma. In this pilot study, we planned to verify the toxicity of intravenous injection of low-dose AO in humans and investigate the anticancer effect of radiation after systemic AO administration (iAOR) for human cancer. PATIENTS ANDMETHODS:
Eight patients with terminal cancer were treated with iAOR.RESULTS:
None of the patients exhibited an adverse effect from AO injection. Three out of the five patients who received a full course of iAOR exhibited clinical or image-based responses, whereas two patients did not.CONCLUSION:
The systemic administration of AO was confirmed not to be toxic in humans, and iAOR was suggested to be potentially effective against radioresistant cancer.Palabras clave
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Bases de datos:
MEDLINE
Asunto principal:
Naranja de Acridina
/
Mutágenos
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
2018
Tipo del documento:
Article
País de afiliación:
Japón