Stereoselective Gold(I)-Catalyzed Intermolecular Hydroalkoxlation of Alkynes.
ACS Catal
; 5(2): 1330-1334, 2015 Feb 06.
Article
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| MEDLINE
| ID: mdl-29291136
ABSTRACT
We report the use of cationic gold complexes [Au(NHC)(CH3CN)][BF4] and [{Au(NHC)}2(µ-OH)][BF4] (NHC = N-heterocyclic carbene) as highly active catalysts in the solvent-free hydroalkoxylation of internal alkynes using primary and secondary alcohols. Using this simple protocol, a broad range of (Z)-vinyl ethers were obtained in excellent yields and high stereoselectivities. The methodology allows for the use of catalyst loadings as low as 200 ppm for the addition of primary alcohols to internal alkynes (TON = 35 000, TOF = 2188 h-1).
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MEDLINE
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En
Revista:
ACS Catal
Año:
2015
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Article
País de afiliación:
Reino Unido