Estrogens and their receptors in the medial amygdala rapidly facilitate social recognition in female mice.
Psychoneuroendocrinology
; 89: 30-38, 2018 03.
Article
en En
| MEDLINE
| ID: mdl-29309995
ABSTRACT
Estrogens have been shown to rapidly (within 1â¯h) affect learning and memory processes, including social recognition. Both systemic and hippocampal administration of 17ß-estradiol facilitate social recognition in female mice within 40â¯min of administration. These effects were likely mediated by estrogen receptor (ER) α and the G-protein coupled estrogen receptor (GPER), as administration of the respective receptor agonists (PPT and G-1) also facilitated social recognition on a rapid time scale. The medial amygdala has been shown to be necessary for social recognition and long-term manipulations in rats have implicated medial amygdalar ERα. As such, our objective was to investigate whether estrogens and different ERs within the medial amygdala play a role in the rapid facilitation of social recognition in female mice. 17ß-estradiol, G-1, PPT, or ERß agonist DPN was infused directly into the medial amygdala of ovariectomized female mice. Mice were then tested in a social recognition paradigm, which was completed within 40â¯min, thus allowing the assessment of rapid effects of treatments. 17ß-estradiol (10, 25, 50, 100â¯nM), PPT (300â¯nM), DPN (150â¯nM), and G-1 (50â¯nM) each rapidly facilitated social recognition. Therefore, estrogens in the medial amygdala rapidly facilitate social recognition in female mice, and the three main estrogen receptors ERα, ERß, and the GPER all are involved in these effects. This research adds to a network of brain regions, including the medial amygdala and the dorsal hippocampus, that are involved in mediating the rapid estrogenic facilitation of social recognition in female mice.
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Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Receptores de Estrógenos
/
Reconocimiento en Psicología
/
Estrógenos
Límite:
Animals
Idioma:
En
Revista:
Psychoneuroendocrinology
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá