<i>CFH</i> and <i>ARMS2</i> genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation.

Vavvas, Demetrios G; Small, Kent W; Awh, Carl C; Zanke, Brent W; Tibshirani, Robert J; Kustra, Rafal

CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation.

Vavvas, Demetrios G; Small, Kent W; Awh, Carl C; Zanke, Brent W; Tibshirani, Robert J; Kustra, Rafal.

Afiliación

Vavvas DG; Department of Ophthalmology Retina Service, Massachusetts Eye and Ear Institute, Harvard Medical School, Boston, MA 02114.
Small KW; Macula and Retina Institute, Los Angeles, CA 90048.
Awh CC; Tennessee Retina, Nashville, TN 37203.
Zanke BW; Department of Medical Affairs, Arctic Medical Laboratories, Grand Rapids, MI 49504.
Tibshirani RJ; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305; tibs@stanford.edu.
Kustra R; Department of Statistics, Stanford University, Stanford, CA 94305.

Proc Natl Acad Sci U S A ; 115(4): E696-E704, 2018 01 23.

Article en En | MEDLINE | ID: mdl-29311295

Asunto(s)

Antioxidantes/uso terapéutico; Degeneración Macular/genética; Degeneración Macular/prevención & control; Proteínas/genética; Zinc/uso terapéutico; Factor H de Complemento/genética; Progresión de la Enfermedad; Humanos

Palabras clave

bootstrap validation; genetic effect modification; macular degeneration; ophthalmology; statistical interaction

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Zinc / Proteínas / Degeneración Macular / Antioxidantes Tipo de estudio: Clinical_trials / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article

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