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Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
Nijsen, Marjoleen J M A; Wu, Fan; Bansal, Loveleena; Bradshaw-Pierce, Erica; Chan, Jason R; Liederer, Bianca M; Mettetal, Jerome T; Schroeder, Patricia; Schuck, Edgar; Tsai, Alice; Xu, Christine; Chimalakonda, Anjaneya; Le, Kha; Penney, Mark; Topp, Brian; Yamada, Akihiro; Spilker, Mary E.
Afiliación
  • Nijsen MJMA; Abbvie Inc, North Chicago, Illinois, USA.
  • Wu F; Novartis Institutes for Biomedical Research, East Hanover, New Jersey, USA.
  • Bansal L; GlaxoSmithKline, King of Prussia, Philadelphia, USA.
  • Bradshaw-Pierce E; Takeda, San Diego, California, USA.
  • Chan JR; Eli Lilly and Company, Indianapolis, Indiana, USA.
  • Liederer BM; Genentech Inc., South San Francisco, California, USA.
  • Mettetal JT; AstraZeneca, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA.
  • Schroeder P; Biogen, Cambridge, Massachusetts, USA.
  • Schuck E; Eisai Inc, Woodcliff Lake, New Jersey, USA.
  • Tsai A; Vertex Pharmaceuticals Incorporated, Boston, Massachusetts, USA.
  • Xu C; Sanofi, Bridgewater, New jersey, USA.
  • Chimalakonda A; Bristol-Myers Squibb, Princeton, New Jersey, USA.
  • Le K; Agios, Boston, Massachusetts, USA.
  • Penney M; UCB, Celltech, Slough, Berkshire, United Kingdom.
  • Topp B; Merck & Co., Inc, Kenilworth, New Jersey, USA.
  • Yamada A; Astellas Pharma Inc., Tokyo, Japan.
  • Spilker ME; Pfizer Worldwide Research and Development, San Diego, California, USA.
CPT Pharmacometrics Syst Pharmacol ; 7(3): 135-146, 2018 03.
Article en En | MEDLINE | ID: mdl-29349875
ABSTRACT
A cross-industry survey was conducted to assess the landscape of preclinical quantitative systems pharmacology (QSP) modeling within pharmaceutical companies. This article presents the survey results, which provide insights on the current state of preclinical QSP modeling in addition to future opportunities. Our results call attention to the need for an aligned definition and consistent terminology around QSP, yet highlight the broad applicability and benefits preclinical QSP modeling is currently delivering.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Farmacología Clínica / Evaluación Preclínica de Medicamentos / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Farmacología Clínica / Evaluación Preclínica de Medicamentos / Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: CPT Pharmacometrics Syst Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos