Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.

Ryan, Veronica H; Dignon, Gregory L; Zerze, Gül H; Chabata, Charlene V; Silva, Rute; Conicella, Alexander E; Amaya, Joshua; Burke, Kathleen A; Mittal, Jeetain; Fawzi, Nicolas L

Ryan, Veronica H; Dignon, Gregory L; Zerze, Gül H; Chabata, Charlene V; Silva, Rute; Conicella, Alexander E; Amaya, Joshua; Burke, Kathleen A; Mittal, Jeetain; Fawzi, Nicolas L.

Afiliación

Ryan VH; Neuroscience Graduate Program, Brown University, Providence, RI 02912, USA.
Dignon GL; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Zerze GH; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Chabata CV; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
Silva R; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
Conicella AE; Graduate Program in Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.
Amaya J; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
Burke KA; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
Mittal J; Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA 18015, USA.
Fawzi NL; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA. Electronic address: nicolas_fawzi@brown.edu.

Mol Cell ; 69(3): 465-479.e7, 2018 02 01.

Article en En | MEDLINE | ID: mdl-29358076

Asunto(s)

Ribonucleoproteína Heterogénea-Nuclear Grupo A-B/química; Ribonucleoproteína Heterogénea-Nuclear Grupo A-B/metabolismo; Esclerosis Amiotrófica Lateral/genética; Esclerosis Amiotrófica Lateral/metabolismo; Esclerosis Amiotrófica Lateral/patología; Arginina/genética; Arginina/metabolismo; Demencia Frontotemporal/genética; Demencia Frontotemporal/metabolismo; Demencia Frontotemporal/patología; Ribonucleoproteína Heterogénea-Nuclear Grupo A-B/genética; Humanos; Cuerpos de Inclusión/genética; Cuerpos de Inclusión/metabolismo; Imagen por Resonancia Magnética/métodos; Metilación; Mutación; Neuronas/metabolismo; Neuronas/patología; Procesamiento Proteico-Postraduccional

Palabras clave

RNP granule; amyotrophic lateral sclerosis; frontotemporal dementia; inclusion body myopathy; intrinsically disordered protein; liquid-liquid phase separation; molecular dynamics simulation; protein aggregation; protein interactions; solution NMR spectroscopy

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ribonucleoproteína Heterogénea-Nuclear Grupo A-B Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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