Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury.
Turk Neurosurg
; 28(6): 889-896, 2018.
Article
en En
| MEDLINE
| ID: mdl-29368318
ABSTRACT
AIM:
To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI). MATERIAL ANDMETHODS:
Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoracic laminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clip compression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysis and biochemical parameters of tumor necrosis factor alpha (TNF-?) and interleukin (IL)-1? were measured.RESULTS:
The resveratrol group had statistically significant lower levels of TNF-?, IL -1?, and terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells.CONCLUSION:
Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to its proven cardioprotective effects.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Traumatismos de la Médula Espinal
/
Apoptosis
/
Fármacos Neuroprotectores
/
Resveratrol
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Turk Neurosurg
Asunto de la revista:
NEUROCIRURGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Turquía