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Pirfenidone prevents radiation-induced intestinal fibrosis in rats by inhibiting fibroblast proliferation and differentiation and suppressing the TGF-ß1/Smad/CTGF signaling pathway.
Sun, Yan-Wu; Zhang, Yi-Yi; Ke, Xin-Jie; Wu, Xue-Jing; Chen, Zhi-Fen; Chi, Pan.
Afiliación
  • Sun YW; Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian, China.
  • Zhang YY; Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian, China.
  • Ke XJ; Department of General Surgery, Quanzhou Municipal Guangqian Hospital, Quanzhou, 362000 Fujian, China.
  • Wu XJ; Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian, China.
  • Chen ZF; Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian, China.
  • Chi P; Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001 Fujian, China. Electronic address: chipan363@163.com.
Eur J Pharmacol ; 822: 199-206, 2018 Mar 05.
Article en En | MEDLINE | ID: mdl-29374548
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piridonas / Traumatismos Experimentales por Radiación / Diferenciación Celular / Fibroblastos / Intestinos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piridonas / Traumatismos Experimentales por Radiación / Diferenciación Celular / Fibroblastos / Intestinos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: China