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CPT2 downregulation adapts HCC to lipid-rich environment and promotes carcinogenesis via acylcarnitine accumulation in obesity.
Fujiwara, Naoto; Nakagawa, Hayato; Enooku, Kenichiro; Kudo, Yotaro; Hayata, Yuki; Nakatsuka, Takuma; Tanaka, Yasuo; Tateishi, Ryosuke; Hikiba, Yohko; Misumi, Kento; Tanaka, Mariko; Hayashi, Akimasa; Shibahara, Junji; Fukayama, Masashi; Arita, Junichi; Hasegawa, Kiyoshi; Hirschfield, Hadassa; Hoshida, Yujin; Hirata, Yoshihiro; Otsuka, Motoyuki; Tateishi, Keisuke; Koike, Kazuhiko.
Afiliación
  • Fujiwara N; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Nakagawa H; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Enooku K; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Kudo Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Hayata Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Nakatsuka T; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Tanaka Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Tateishi R; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Hikiba Y; Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation, Tokyo, Japan.
  • Misumi K; Department of Pathology, The University of Tokyo, Tokyo, Japan.
  • Tanaka M; Department of Pathology, The University of Tokyo, Tokyo, Japan.
  • Hayashi A; Department of Pathology, The University of Tokyo, Tokyo, Japan.
  • Shibahara J; Department of Pathology, The University of Tokyo, Tokyo, Japan.
  • Fukayama M; Department of Pathology, The University of Tokyo, Tokyo, Japan.
  • Arita J; Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Hasegawa K; Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, The University of Tokyo, Tokyo, Japan.
  • Hirschfield H; Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Hoshida Y; Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Hirata Y; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Otsuka M; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Tateishi K; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
  • Koike K; Department of Gastroenterology, The University of Tokyo, Tokyo, Japan.
Gut ; 67(8): 1493-1504, 2018 08.
Article en En | MEDLINE | ID: mdl-29437870
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carnitina / Carnitina O-Palmitoiltransferasa / Carcinoma Hepatocelular / Enfermedad del Hígado Graso no Alcohólico / Neoplasias Hepáticas / Obesidad Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Año: 2018 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carnitina / Carnitina O-Palmitoiltransferasa / Carcinoma Hepatocelular / Enfermedad del Hígado Graso no Alcohólico / Neoplasias Hepáticas / Obesidad Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Gut Año: 2018 Tipo del documento: Article País de afiliación: Japón