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Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.
Knutson, Daniel E; Kodali, Revathi; Divovic, Branka; Treven, Marco; Stephen, Michael R; Zahn, Nicolas M; Dobricic, Vladimir; Huber, Alec T; Meirelles, Matheus A; Verma, Ranjit S; Wimmer, Laurin; Witzigmann, Christopher; Arnold, Leggy A; Chiou, Lih-Chu; Ernst, Margot; Mihovilovic, Marko D; Savic, Miroslav M; Sieghart, Werner; Cook, James M.
Afiliación
  • Knutson DE; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Kodali R; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Divovic B; Department of Pharmacology, Faculty of Pharmacy , University of Belgrade , Vojvode Stepe 450 , 11221 Belgrade , Serbia.
  • Treven M; Department of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , Spitalgasse 4 , A-1090 Vienna , Austria.
  • Stephen MR; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Zahn NM; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Dobricic V; Department of Pharmaceutical Chemistry, Faculty of Pharmacy , University of Belgrade , Vojvode Stepe 450 , 11221 Belgrade , Serbia.
  • Huber AT; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Meirelles MA; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Verma RS; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Wimmer L; TU Wien-Institute of Applied Synthetic Chemistry , Getreidemarkt 9/163 , A-1060 Vienna , Austria.
  • Witzigmann C; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Arnold LA; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
  • Chiou LC; Graduate Institute of Acupuncture Science , China Medical University , Taichung 40402 , Taiwan.
  • Ernst M; Department of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , Spitalgasse 4 , A-1090 Vienna , Austria.
  • Mihovilovic MD; TU Wien-Institute of Applied Synthetic Chemistry , Getreidemarkt 9/163 , A-1060 Vienna , Austria.
  • Savic MM; Department of Pharmacology, Faculty of Pharmacy , University of Belgrade , Vojvode Stepe 450 , 11221 Belgrade , Serbia.
  • Sieghart W; Department of Molecular Neurosciences, Center for Brain Research , Medical University of Vienna , Spitalgasse 4 , A-1090 Vienna , Austria.
  • Cook JM; Department of Chemistry and Biochemistry, Milwaukee Institute for Drug Discovery , University of Wisconsin-Milwaukee , 3210 N. Cramer St. , Milwaukee , Wisconsin 53211 , United States.
J Med Chem ; 61(6): 2422-2446, 2018 03 22.
Article en En | MEDLINE | ID: mdl-29481759
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de GABA-A / Antagonistas del GABA Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores de GABA-A / Antagonistas del GABA Límite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos