Colon capsule versus computed tomography colonography for colorectal cancer screening in patients with positive fecal occult blood test who refuse colonoscopy: a randomized trial.
Endoscopy
; 50(8): 761-769, 2018 08.
Article
en En
| MEDLINE
| ID: mdl-29486502
ABSTRACT
OBJECTIVE:
Some patients (10â%â-â32â%) with a positive guaiac fecal occult blood test (gFOBT) do not undergo the recommended colonoscopy. The aim of this study was to compare video capsule endoscopy (VCE) and computed tomography colonography (CTC) in terms of participation rate and detection outcomes when offered to patients with a positive gFOBT who did not undergo the recommended colonoscopy.METHODS:
An invitation letter offering CTC or VCE was sent to selected patients after randomization. Acceptance of the proposed (or alternative) procedure and procedure results were recorded. Sample size was evaluated according to the hypothesis of a 13â% increase of participation with VCE.RESULTS:
A total of 756 patients were targeted. Following the invitation letter, 5.0â% (19/378) of patients underwent the proposed VCE and 7.4â% (28/378) underwent CTC, (Pâ=â0.18). Following the letter, 9.8â% (37/378) of patients in the VCE group underwent a diagnostic procedure (19 VCE, 1 CTC, 17 colonoscopy) vs. 10.8â% in the CTC group (41/378 28 CTC, 13 colonoscopy; Pâ=â0.55). There were more potentially neoplastic lesions diagnosed in the VCE group than in the CTC group (12/20 [60.0â%] vs. 8/28 [28.6â%]; Pâ=â0.04). Thus, 15/20 noninvasive procedures in the VCE group (19 VCE, 1 CTC; 75.0â%) vs. 10/28 in the CTC group (35.7â%; Pâ=â0.01) resulted in a recommendation of further colonoscopy, but only 10/25 patients actually underwent this proposed colonoscopy.CONCLUSION:
Patients with a positive gFOBT result who do not undergo the recommended colonoscopy are difficult to recruit to the screening program and simply proposing an additional, less-invasive procedure, such as VCE or CTC, is not an effective strategy.ClinicalTrials.govNCT02558881TRIAL REGISTRATION Randomized, controlled trial NCT02558881 at clinicaltrials.gov.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Neoplasias Colorrectales
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Aceptación de la Atención de Salud
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Colonoscopía
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Colonografía Tomográfica Computarizada
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Endoscopía Capsular
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Detección Precoz del Cáncer
Tipo de estudio:
Clinical_trials
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Diagnostic_studies
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Guideline
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Screening_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Endoscopy
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia